The use of intrathecal antibiotics for bacterial meningitis: what evidence do we have?

The treatment of meningitis is a complex issue when it comes to multi-resistant antibiotic (ATB) bacteria, limiting the drug options that can cross blood-brain barrier and effectively reach subarachnoid space. impact on effectiveness therapeutic arsenal available, due indiscriminate use antibacterial global scale, increases chances failure initial empirical persistence despite culture targeting at pathogens, while not obtaining satisfactory results. Thus, strategies optimize delivery antibacterials pathology site involves using pharmacokinetic mechanism in order achieve desired effect through intrathecal administration. During this review, we aimed evaluate therapy patients infected with multidrug-resistant bacteria analyze possible adverse effects.